This is an analysis of 39 patients studied at the Yonsei Medical Center from January, 1976 to March 1979. Of these35 patient were suspected of having hypothalamic insufficiency and subjected to the L-Dopa stimulation test to observe growth hormone sceretory function, while four acromegaly patient received the glucose loading test and L-Dopa stimulation test.
The results are as follows:
1. The basal level of GH in the various disease was as follows:
a. The basal level was lower than the control level but was not statistically significantb. In diabetes the mean value tended to be higher than the control level but was not
significant statistically
c. In all four acromegaly patients the GH level was significantly higher than the controllevel
2. Of 13 patients with diabetes, nine had diabetic retinoparhy, and of those nine, six showed increased L-Dopa response. However, of the four non retinopathic DM patients, only one showed increased response to L-Dopa.
3. Two patients out of ten with Sheehan´s syndrome responded to L-Dopa stimulation.
4. One Patient of eight with pituitary chromophobe adenoma responded to L-Dopa. stimulation.
5. Four acromegaly patients revealed 3 acidophilic adenoma and one chromophobe adenoma histologically. Of patients receiving the L-Dopa stimulation test. Two showed a - paradoxical response. Two patients who received the glucose loading test showed supressed
response.
G. Of two craniopharyLgiomaO patients, one showed increased GH response after L-Dopa stimulat?cn. Increased response of GH after L-Dopa stimulation was seen in one of two craniopharyngiorna patients and also in one of two patients with si- ´lire.
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